Postdoctoral Position in Antibiotic Development (24 months)

Human tissue models to predict antibiotic efficacy against non-tuberculous mycobacteria

 

 

The Biozentrum of the University of Basel is a leading life science institutes worldwide, dedicated to understanding the fundamental principles of biology. The Department of Biomedicine (DBM), a joint initiative of the University of Basel and the University Hospitals Basel, unites basic and clinical research to advance the understanding of human disease. Both institutions are part of the NCCR AntiResist, a Swiss-wide research consortium developing new strategies against antibiotic-resistant bacterial infections.

The position

We are looking for an ambitious postdoctoral researcher to study antibiotic efficacy against non-tuberculous mycobacteria (NTM) in a physiologically relevant human airway infection model. The position is shared between the Boeck Lab (DBM) and the Jenal Lab (Biozentrum), is embedded in the NCCR AntiResist research network, and includes a close collaboration with A&J Science, a company advancing new antibacterial compounds.

The project

Pulmonary NTM infections are increasing worldwide and remain notoriously difficult to cure. How NTM colonise and persist in human airways and how they respond to antibiotics in tissue remains poorly understood. The Jenal Lab has established a fully differentiated air-liquid interface (ALI) human airway model and used it to dissect how Pseudomonas aeruginosa breaches the respiratory barrier (Nature Microbiology 2024). The Boeck Lab has developed large-scale imaging approaches to measure antibiotic killing dynamics across NTM strains and drugs, linking drug tolerance to bacterial genotypes and clinical outcome (Nature Microbiology 2026). This project brings both platforms together to establish NTM infection in human airway tissues and build a tissue-based drug efficacy platform for antimycobacterial compounds.

Your role

You will establish NTM infection in human ALI airway epithelium and characterise infection dynamics. Building on this, you will develop and validate a tissue-based antibiotic efficacy platform, measuring bacterial growth and killing dynamics, intracellular drug activity, and tissue integrity during treatment. You will test novel antimicrobial compounds alongside standard-of-care antibiotics and compare tissue-based efficacy with conventional drug testing. You will lead the project scientifically and work at the interface of two academic labs and an industry partner.

Your profile

We are looking for a candidate with a strong track record in infection biology.

·                  PhD in infection biology, microbiology, cell biology, or a related discipline

·                  Experience with microbiology techniques, such as bacterial culture, genetic manipulation, and imaging

·                  Experience with mammalian cell culture (organoid or ALI culture is particularly valuable)

·                  Ability to design, execute, and troubleshoot experiments independently

·                  Strong motivation, scientific curiosity, and drive

·                  Ability to work collaboratively in a multidisciplinary consortium

What we offer

·                  A fully funded 2-year postdoctoral position within the NCCR AntiResist

·                  Access to cutting-edge technologies, such as high-content imaging and confocal microscopy

·                  An established human airway infection platform ready for adaptation to NTM

·                  Close interaction with drug development partners

·                  A vibrant, international, and collaborative research environment at the University of Basel

·                  Support for independent funding applications and career development

·                  Competitive salary and excellent quality of life in Basel, Switzerland

How to apply

Please upload a single PDF including a motivation letter, a CV, academic transcripts, contact details of at least two references, and a brief description of a project you would be excited to pursue. Applications will be reviewed on a rolling basis until the position is filled.

 

[Show complete description]

Your privacy is important to us.

When you apply through our system, you have to provide personal information in the course of the evaluation process. Have a look at our data privacy policy to find out how we handle and protect your data.

By submitting the data in this form, you are consenting to this policy.

Personal Details

Please enter your personal details

Firstname*:
Lastname*:
Date of birth*:
Place of birth*:
Nationality*:
Sex*:

Contact address

Street*:
ZIP*:
City*:
Country of residence*:
Phone*:
Email*:

Degrees obtained

Complete at least one degree and date.
Please attach a copy of diplomas and grades (A4 size) with this form (below).

Language skills

English proficiency*:
German proficiency*:

Your application

Letter of Motivation

Provide your cover letter here

Cover letter:
Professional experience

Please provide the main highlights of your CV here. You can upload your complete CV as a file in the end.

CV Highlights:
What makes you unique for this position?
In a few words,... :
References

Please provide contact information for up to 3 references

Additional information

Comments

Please include here any additional information you feel is relevant to your application (work permit, availability, etc.)

Further comments:
Outside interests and hobbies
Let us get to know you better:

Supporting files

Please provide additional documents: Formatted CV and Cover letter, Reference letters, other relevant documents, ...)

This form can be edited and saved again until the deadline. After the deadline your application is automatically submitted and becomes inaccessible.

* Fields must be filled out for initial submission