How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world’s leading life sciences institutes. is one of the world’s leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!
The Keller Valsecchi group explores the epigenetic mechanisms and physiological relevance of gene dosage in regulating cellular function in male and female animals - from individual genes to chromosome-wide scales. We are looking for someone that helps our group understanding the molecular mechanisms governing the regulation of sex chromosomes in non-model organisms.
Essential Qualifications
Any of the following qualification or interests would be an asset
Key Competencies
The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV, diplomas and two reference letters. Review of applications will start immediately and proceed until the position is filled. Only online applications will be considered.
For any informal inquiries, please contact: c.kellervalsecchi@unibas.chStarting Date: January 2026 or by agreement
The Biozentrum of the University of Basel is one of the world’s leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!
The Jenal Lab at the Biozentrum of the University of Basel is seeking a highly motivated and skilled postdoc with expertise in molecular biology, biochemistry and/or structural biology to join our team. This position offers an exciting opportunity to contribute to cutting-edge research in structure-based discovery of anti-biofilm compounds.
Our research group at the Biozentrum is embedded in the National Centre of Competence in Research (NCCR) AntiResist. We develop and use state-of-the-art organoid technology to better understand human infections and foster antibiotic discovery. We conduct a wide range of assays including cellular and molecular microbiology, advanced microscopy, omics etc. to reach a detailed understanding of human infections, host response and drug treatment.
The project aims to develop novel anti-biofilm compounds that can be used to treat biofilm-related infections caused by a range of bacterial pathogens. Based on structural data demonstrating how an existing anti-biofilm compound binds to and activates its specific target in Pseudomonas aeruginosa, we will design, develop and test novel anti-biofilm compounds with broader activity against the WHO priority pathogens Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. You will be working in a trans-national research consortium including experts in structure-based modelling, structure biology and chemistry.
PhD in Molecular Biology, Microbiology, Biochemistry or Structural Biology with research experience in any of these areas. You are highly motivated, organized, independent, flexible, with excellent communication and strong team-player skills.
This position offers an exciting opportunity for a highly motivated individual to contribute to a vibrant international research community and to tackle challenging questions in infection biology and drug development. The Biozentrum is a front-line international research environment with cutting-edge research infrastructure and excellent working conditions. The position is initially for one year, with the possibility of further extension. Salary and benefits according to University of Basel standards.
Basel is an international city with people from 150 nations. Located on the border where three countries meet, Switzerland-Germany-France, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Please apply online.
The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV, diplomas and two reference letters. Review of applications will start immediately and proceed until the position is filled. Only online applications will be considered.
For any informal enquiries, please contact: jenal-recruitment@unibas.chStarting Date: As soon as possible
The Biozentrum of the University of Basel is one of the world’s leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!
The Jenal Lab at the Biozentrum of the University of Basel is seeking a highly motivated and skilled postdoc with expertise in molecular biology, microscopy and/or phage biology to join our team. This position offers an exciting opportunity to contribute to cutting-edge research at the interface of bacterial signal transduction and phage biology.
Our research group at the Biozentrum is embedded in the National Centre of Competence in Research (NCCR) AntiResist. We develop and use state-of-the-art organoid technology to better understand human infections and foster antibiotic discovery. We conduct a wide range of assays including cellular and molecular microbiology, advanced microscopy, omics etc. to reach a detailed understanding of human infections, host response and drug treatment.
The aim of the project is to understand the role of the second messenger c-di-GMP in E. coli bacteriophage infection and propagation and to investigate mechanisms that allow the host to escape phage killing by modulating its own signal transduction pathways. You will be working in a dynamic team of researchers with broad expertise in molecular biology, microbiology and infection biology and you will be interacting with researcher from neighboring disciplines like structural biology or computational biology.
You have a PhD in Molecular Biology, Microbiology, Biochemistry or related fields with research experience in any of these areas. You are highly motivated, organized, and flexible. You have good communication skills and you are able to work both independently and in a team with other researchers.
This position offers an exciting opportunity for a highly motivated individual to contribute to a vibrant international research community and to tackle challenging questions in infection biology and drug development. The Biozentrum is a front-line international research environment with cutting-edge research infrastructure and excellent working conditions. The position is initially for one year, with the possibility of further extension. Salary and benefits according to University of Basel standards.
Basel is an international city with people from 150 nations. Located on the border where three countries meet, Switzerland-Germany-France, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
Please apply online.
The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV, diplomas and two reference letters. Review of applications will start immediately and proceed until the position is filled. Only online applications will be considered.
For any informal enquiries, please contact: jenal-recruitment@unibas.chHow does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world’s leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!
The research group of Sebastian Hiller is looking to recruit a highly motivated and curious Postdoctoral fellow, starting immediately or as per agreement.
In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we investigate the molecular underpinnings of gene regulation in muscle plasticity at the atomic level. At the center of this regulation lies PGC-1α, a transcriptional co-activator and master regulator of metabolic processes. PGC-1α dysfunction has been linked to obesity, diabetes, muscular dystrophies, neurodegenerative diseases, and cancer. Despite its importance, the molecular mechanisms by which PGC-1α—a large, predominantly disordered protein with only a single structured RRM domain—senses cellular metabolic states and translates this information into transcriptional activation remain elusive.
This postdoctoral project aims to unravel the molecular mechanisms of PGC-1α function by combining advanced biophysical methods, with a particular emphasis on NMR spectroscopy for structural and dynamic insights into intrinsically disordered proteins, as well as complementary biophysical approaches to characterize protein function and interaction. By applying these techniques, we seek to uncover how PGC-1α integrates signals to regulate transcription, providing fundamental insights into metabolism and disease. The work is a close collaboration with the group of Prof. Christoph Handschin, complementing our structural research with genetic elucidation of structure-function aspects, spanning from molecular biology to animal physiology.
Required:
Desirable:
Please submit your application including:
Deadline: Review of applications will start immediately and continue until the position is filled.
Contact: Sebastian Hiller (sebastian.hiller@unibas.ch)
Join us in uncovering the molecular secrets of PGC-1α and advancing our understanding of metabolism in health and disease!
NCCR AntiResist aims to train the next generation of researchers and clinicians in infectious diseases using novel interdisciplinary approaches. To support this aim, NCCR AntiResist awards unique PhD Fellowships in Antibiotic Discovery.
We invite talented and ambitious young scientists from all over the world to join our NCCR AntiResist community. Our fellowships are particularly well suited for students from the three major research fields of the NCCR AntiResist: clinical research, infection biology and engineering.
NCCR AntiResist aims to train the next generation of researchers and clinicians in infectious diseases using novel interdisciplinary approaches. To support this aim, NCCR AntiResist is awarding a unique, annual Research Fellowship in Infection and Treatment for Clinicians.
The Research Fellowship for Clinicians supports career development in academic medicine, educates the next generation of clinicians in areas relevant to infection and treatment, and fosters the growth of clinician-scientists committed to bridging clinical practice and basic research. It aims to strengthen the translational bridge between basic science and clinical practice within the framework of NCCR AntiResist. Further information about the role can be found on our website.
We invite talented and ambitious young clinicians with an interest in basic and translational infectious disease research to join our NCCR AntiResist community.